| OXR1

Oxidation resistance protein 1 is a protein that is encoded by the OXR1 gene.Loss of OXR1 function causes decline of the retromer complex.Located in mitochondrion. Implicated in cerebellar hyplasia/atrophy, epilepsy, and global developmental delay.OXR1 (Oxidation Resistance 1) is a Protein Coding gene. Diseases associated with OXR1 include Cerebellar Hypoplasia/Atrophy, Epilepsy, And Global Developmental Delay and Cerebellar Hyplasia/Atrophy, Epilepsy, And Global Developmental Delay. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity. An important paralog of this gene is NCOA7.
 

| Typical data

As the OD values of the standard curve may vary according to the conditions of the actual assay performance (e.g. operator, pipetting technique, wash technique or temperature effects), the operator should establish a standard curve for each test. Typical standard curve and data are provided below for reference only.

 

Concentration (ng/mL)	40	20	10	5	2.5	1.25	0.625	0
OD	2.22	1.56	0.92	0.63	0.42	0.25	0.18	0.08
Corrected OD	2.14	1.48	0.84	0.55	0.34	0.17	0.1	-

 

| Repeatability

Intra-assay Precision (Precision within an assay)：CV% < 10%; Inter-assay Precision (Precision between assays)：CV% < 10%
 

| Recovery

The recovery of Human OXR1 spiked at three different levels in samples throughout the range of the assay was evaluated in various matrices.

 

Sample Type	Range(%)	Average Recovery(%)
Tissue Homogenates(n=8)	84-101	95
Cell Lysates(n=8)	96-108	105

 

| Linearity

Samples were spiked with high concentrations of Human OXR1 and diluted with Universal Diluent to produce samples with values within the range of the assay.

 

		Tissue Homogenates(n=4)	Cell Lysates(n=4)
1 : 2	Range (%)	84-95	90-110
	Average (%)	91	96
1 : 4	Range (%)	89-102	105-114
	Average (%)	94	107